Effects of Long Acting Oxytetracycline on Contagious Bovine Pleuropneumonia Experimentally Infected Cattle

Authors

  • Beatrice Otina Department of Public Health, Pharmacology and Toxicology, University of Nairobi, P. O. Box 29053-00625, Nairobi Kenya
  • Philip Kitala Department of Public Health, Pharmacology and Toxicology, University of Nairobi, P. O. Box 29053-00625, Nairobi Kenya
  • Lilly Bebora Department of Veterinary Pathology, Microbiology and Parasitology, University of Nairobi, Kenya
  • Moses Olum Department of Protozoology, KALRO-Veterinary Science Research Institute, Muguga, Kenya
  • Alexander Kipronoh Department of Bacteriology, KALRO-Veterinary Science Research Institute, Muguga, Kenya
  • Lizzie Chesang Global Alliance for Livestock Veterinary Medicines (GALVmed)
  • Kristin Stuke Global Alliance for Livestock Veterinary Medicines (GALVmed)
  • Hezron Wesonga Department of Bacteriology, KALRO-Veterinary Science Research Institute, Muguga, Kenya

DOI:

https://doi.org/10.4314/tjs.v48i4.20

Abstract

Contagious bovine pleuropneumonia is an important disease of cattle. Many strategies employed for its eradication and control have had shortcomings. This study was conducted to determine the effects of long acting Oxytetracycline on its course. The study involved 30 indigenous zebu cattle sourced from an area free of the disease, infected by contact transmission and randomly allocated to Oxytetracycline or saline treatment groups. Clinical observations were recorded on the two groups concurrently. Cattle were tested for the disease using complement fixation test. The mean clinical scores of the groups for each observation was compared post treatment on GENSTAT using unpaired  t-test for single sample in groups. Full post-mortem was conducted on the cattle and samples collected for  Mmm  SC  isolation. The clinical scores were worse in the control treatment group; there was no fever in the Oxytetracycline-treated group post treatment. Lesions were observed in 93% of the control and 27% of the Oxytetracycline-treated group. In this study, as in others, Oxytetracycline was shown to lower the severity of the clinical signs of the disease. This is important at slaughter houses meat inspection where decision on whether to pass or condemn the animal is based on the clinical signs and post-mortem findings.

Keywords:    Contagious bovine Pleuropneumonia, Oxytetracycline, Bovine respiratory distress, Trans- boundary diseases

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Published

2022-12-31

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Articles