Modelling the Effects of Antiretroviral Therapy on Kidney Diseases Among HIV Infected Individuals in Tanzania

Authors

  • Janeth Pancras Mchwampaka Eastern Africa Statistical Training Center, P.O. Box 35103 Dar es Salaam, Tanzania
  • Eunice Mureithi Department of Mathematics, University of Dar es Salaam, P.O. Box 35062, Dar es Salaam, Tanzania
  • Nyimvua Shaban Mbare Department of Mathematics, University of Dar es Salaam, P.O. Box 35062, Dar es Salaam, Tanzania

Abstract

This study examined the role of highly active antiretroviral therapy (HAART) in the dynamics
of kidney diseases among HIV-infected individuals. A deterministic model was formulated for
the dynamics of kidney disease in HIV-infected people with HAART as treatment in the
model. Numerical simulations showed that though HAART reduces HIV progression to the
AIDS stage, there is an increase in HIV-related kidney diseases. Also, the result obtained in
this study showed that reducing the effective contact rate of HIV and improving the
effectiveness of HAART by 99% in preventing the progression from HIV without symptoms
group to HIV-related kidney diseases can decrease the prevalence of HIV-related kidney
diseases. Therefore, based on the findings obtained to reduce the population of HIV-related
kidney diseases in the general population Pharmacists should focus on improving HAART
which will reduce the progression of kidney diseases from HIV.

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Published

2025-03-25

Issue

Vol. 50 No. 5 (2024)

Section

Mathematics and Computational Sciences