BIOACTIVITIES OF EXTRACTS, DEBROMOLAURINTEROL AND FUCOSTEROL FROM MACROALGAE SPECIES

Authors

  • Sartaz Begum Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzani
  • Stephen S. Nyandoro Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
  • Amelia S. Buriyo Botany Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35060, Dar es Salaam, Tanzania
  • John J. Makangara 3Chemistry Department, College of Natural and Mathematical Sciences, The University of Dodoma, P.O. Box 338, Dodoma, Tanzania
  • Joan J. E. Munissi Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
  • Sandra Duffy Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Q1d 4111, Australia
  • Vicky M. Avery Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Q1d 4111, Australia
  • Mate Erdelyi 5Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden

Abstract

Parasitic diseases including malaria, and other numerous microbial infections and physiological
diseases are threatening the global population. Tanzanian coast shores are endowed with a
variety of macroalgae (seaweeds), hitherto unsystematically explored to establish their biomedical
potentials. Thus, antiplasmodial activity using malarial imaging assay, antimicrobial activity
using microplate dilution technique, antioxidant activity using DPPH radical scavenging method
and cytotoxicity using brine shrimp test were carried out on crude extracts from the selected
species of algae (Acanthophora spicifera, Cystoseira myrica, Cystoseira trinodis, Laurencia
filiformis, Padina boryana, Sargassum oligocystum, Turbinaria crateriformis, Ulva fasciata and
Ulva reticulata) occurring along the coast of Tanzania. The extracts showed antimicrobial
activities with MIC ranging from 0.3- 5.0 µg/mL against Staphylococcus aureus, Streptococcus
pyogenes, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Cryptococcus
neoformans; DPPH radical scavenging activity at EC50 1.0- 100 µg/mL and cytotoxicity on brine
shrimp larvae with LC50 value ranging from20 - 1000 µg/mL. The extracts from C. myrica and P.
boryana inhibited growth of Plasmodium falciparum (3D7 strain) by 80 and 71%, respectively at
40 µg/mL while a sesquiterpene debromolaurinterol (1) which was chromatographically isolated
from C. myrica exhibited antiplasmodial activity with IC50 20 µM whereas a sterol fucosterol (2)
from P. boryana showed weak activity at 40 µM. Bioactivities portrayed by the investigated
extracts indicate their ingredients as potential sources of bioactive agents that warrant further
explorations.

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Published

2025-03-28

Issue

Vol. 44 No. 2 (2018)

Section

Articles